Quality evaluation and dissolution profile of hydrochlorothiazide tablets available in Salvador-BA, Brazil

Introduction: hydrochlorothiazide is a diuretic drug indicated for the continuoustreatment of hypertension. The presented as medicine in form tabletscontaining only one active agent or combined formulations with concentrationsof 12.5, 25 and 50 mg. mg dosage most widely used medical therapy.Therefore, considering incidence hypertension prolonged use drug, it isnecessary to determine quality tablets available on public andprivate pharmacies Salvador, Bahia. Complaints regarding compromised qualityof products stored drugstores are reported very often. Material Methods:following monograph, consequently pharmacopoeial methods, thisstudy aimed carry out control, physicochemical microbiological testingof medicines containing hydrochlorothiazide, including trade name (reference – R),generic (G) similar (S) medicine, which provided by National Health Service(aka SUS Sistema Único de Saúde). Results: was observed that samples themedicines: R, G S showed complies tests, exceptfor assay generic content specification.